STRAIN-SPECIFIC, WHOLE FLOWER PRODUCTS

 
WHY STRAIN SPECIFIC?

Consider if previously you have taken a medication that hasn't agreed with you. If you have, you will likely avoid taking it in the future, if possible. The same goes for when you find a medication that works for you. You would like to be able to stay with that specific medication as opposed to even a slight variation such as switching between a brand name and a generic.

The same is true with cannabis. The differences are the source of the cannabinoids and the type of strain. Each strain is unique, with the strains having unique, typically funny names given by the cultivators who have grown them. A strain's effects vary with its unique cannabinoid and terpene profiles, along with other compounds that make the strain what it is.  The terpenes act somewhat as a genetic fingerprint for each strain.  The terpenes are the essential oil compounds that provide the unique flavor and aroma. Terpenes also have additional therapeutic benefits, which have been accepted as Generally Recognized as Safe (GRAS) by the FDA.

 

CBD, THC, CBG, CBN etc. are just one piece of the cannabis puzzle. If you're only seeing that information on product labels, you're missing a lot of other factors that will determine how you're going to respond to cannabis.

 

When you are trying different formulations, it's important to know specifically where the cannabinoids came from. A very common practice today is to take a cannabis strain and create a cannabis extract oil with an emphasis on creating the highest percentage concentration of THC or CBD oil, and then adding secondary terpenes into the product. This process does not allow you to accurately track what specifically has worked for you.

 

We believe that full spectrum is the most effective way to consume cannabis. However, the term full spectrum is often widely misused contributing to the already mounting confusion when trying to differentiate between all the products out there. Let us break down what full spectrum should include. When making a full-spectrum extract oil, the terpenes are "steam lifted" off of the flower before processing. Then the flower is processed and minimally refined to preserve the widest range of cannabinoids, as opposed to the highest CBD or THC concentration. The terpenes extracted at the beginning are reintroduced back in. The formulation contains all of the native compounds of the plant with nothing added, and that is what full spectrum truly means.

 

Before the discovery of ECS, terms like Indica, Sativa, hybrid, and ratios, combined with anecdotal feedback from patients, were the only tools available when helping people make a decision on how cannabis might affect them. Today we know there is so much more to how cannabis works within the body beyond those terms. We know that cannabis is not a one size fits all, and everyone responds differently. Much like traditional medicine, what works for one person really might have a different effect for someone else. When you find something that works or doesn't work for you, knowing what the strain(s) are is the most important piece of information.

 
WHOLE FLOWER CANNABIS CBD vs SINGLE MOLECULE CBD FROM HEMP OR ISOLATE

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There are many different opinions floating around the internet about the difference between CBD from whole flower cannabis versus CBD from hemp or isolate. Sana Sana Formulas strongly believes in providing only information and studies that have been reviewed thoroughly. Instead of adding another opinion into the mix, Sana Sana would rather provide you with vetted information on the topic and allow you to draw your own conclusion.

 

Several scientific studies report that pure, single-molecule CBD, while possibly effective at high doses in preclinical tests, has a much tighter therapeutic window and is much less potent compared with a whole plant CBD-rich concentrate.

 

Moreover, whether synthesized in a lab or heavily refined from industrial hemp paste, pure CBD isolates lack the full array of phytocannabinoids and medicinal terpenes found in whole plant CBD-rich cannabis, which includes hundreds of biologically active components. These constituents interact with CBD and THC to create what scientists refer to as an “entourage” or “ensemble” effect, so that the therapeutic impact of the whole plant is greater than the sum of its parts.

 

Problematic drug interactions are much more likely with high doses of single-molecule CBD, which can inhibit the metabolism of 60% of marketed pharmaceuticals. At high doses, CBD will deactivate certain cytochrome P450 enzymes in the liver, thereby altering how we metabolize a wide range of medications, including clobazam, an anti-epileptic drug. This was evident in GW Pharmaceuticals Epidiolex  trials, when children with intractable seizure disorders were given CBD doses ranging from 5 to 50 milligrams per kilogram of body weight. Doctors had to adjust the amount of clobazam the children were taking because of potentially dangerous drug-drug interactions with Epidiolex .

 

The high-dose, single-molecule CBD regimen employed by GW Pharmaceuticals is much higher than the 1 milligram per kilogram of artisanal whole plant CBD-rich oil that cannabis clinicians in California and elsewhere recommend as an initial dosage for treating pediatric epilepsy. While there is no clearly  established cut-off dose in which CBD does not interact with other drugs, the dose is certainly lower than what GW Pharmaceuticals used in their study, and fewer problems are reported, when full-spectrum CBD-rich cannabis products are used as opposed to CBD isolates.

- LUMIR HANUŠ
"IT HAS BECOME CLEAR THAT THE HEALING POTENTIAL OF THE WHOLE PLANT IS STRONGER THAN ISOLATED COMPOUNDS ON THEIR OWN."
WHAT ARE TERPENES? AND WHY ARE THEY IMPORTANT?

Terpenes are the essential oil compounds found in plants. When you peel an orange, the aromatic mist that is produced are terpenes. Most commonly known in the world of aromatherapy, terpenes also have a very important role in cannabis. Terpenes act as a genetic fingerprint for cannabis strains while also providing a road map to specific therapeutic benefits. There is also evidence of terpenes enhancing the effects of specific cannabinoids.

My current research focuses on finding out what compounds besides cannabinoids play important roles in cannabis treatment of various diseases. Be it terpenes, flavonoids, polyphenols, or other substances, we need to find out how they enhance or suppress the healing effects of cannabis.” 

-Lumír Hanuš, one of the chemists who isolated the first known endocannabinoid in the human brain. They named it anandamide, after the Sanskrit word for joy or bliss.

TERPENE DEEP DIVE

Scientists have identified and characterized the molecular structure of some 20,000 terpenes, which comprise the largest category of plant chemicals. These can be further broken down into monoterpenes, diterpenes, and sesquiterpenes, depending on the number of repeating units of a five-carbon molecule called isoprene, the structural hallmark of all terpenoid compounds.

Around 200 terpenes have been found in cannabis, but only a few appear in amounts substantial enough to be noteworthy. Also, the terpenoid profile can vary considerably from strain to strain. Certain terpenoids dilate capillaries in the lungs, enabling smoked or vaporized THC to enter the bloodstream more easily. Nerolidol, a sedative terpenoid, is a skin penetrant that increases permeability and potentially facilitates cannabinoid absorption when applied topically for pain or skin conditions.

Terpenoids and cannabinoids both increase blood flow, enhance cortical activity, and kill respiratory pathogens. In an article in the British Journal of Pharmacology that discussed wide-ranging therapeutic benefits of terpenoids, Dr. Ethan Russo reported that cannabinoid-terpenoid interactions “could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal, and bacterial infections.”

The most abundant terpenes in cannabis are myrcene, pinene, limonene, linalool, eucalyptol, and caryophyllene. The variation in the ratios among these terpenes is what produces the wide range of aromas found in cannabis.

In cannabis, terpenes are exuded in the resin and confer it with a sticky and viscous quality.

Terpenes are not just responsible for aroma, they also provide important biological and therapeutic activity. It has been scientifically shown that the essential oils of plants have therapeutic properties and are the pharmacological base of aromatherapy. These oils and pure terpenes can also be used as flavorings in the food industry because they are nontoxic compounds. The therapeutic properties will specifically depend on the terpene in question.

The fact that most terpenoid compounds are common components of the human diet and “generally recognized as safe” by the Food and Drug Administration has made research possible, and scientists employed by flavor and fragrance manufacturers have investigated their properties over the years. 

PROMINENT TERPENES FOUND IN CANNABIS STRAINS AND ASSOCIATED BENEFITS

Terpinolene

  • Antioxidant

  • Antitumor

  • Antibacterial 

  • Antifungal

  • Treatment on insomnia

Also found in: oregano, marjoram, cumin, lilac, some citrus rind and conifers

Phytol

  • Used in the synthesis of vitamins E and K

  • Antioxidant properties

Also found in: green tea

β-Myrcene

  • Antitumor

  • Anti-inflammatory

  • Used in the treatment of spasms, insomnia, and pain

  • Lowers the resistance across the blood–brain barrier, allowing itself and many other chemicals to cross the barrier easier and more quickly

Also found in: fresh mango, hops, bay leaves, eucalyptus, lemongrass, and many other plants

α-Pinene

  • Bronchodilator in the treatment of asthma

  • Anti-inflammatory

  • Promotes alertness and memory retention

  • Antimicrobial, both bacterial and viral

 

Also found in: conifer trees, orange peels among others, and known for its sharp sweet odor

Limonene

  • Gastric reflux

  • Antifungal agent including toenail fungus

  • Depression and anxiety

  • Assists in the absorption of other terpenoids and chemicals through the skin, mucous membranes, and digestive tract

  • Shown to have effective antitumor activity while at the same time being an immunostimulant

Also found in: citrus fruit

β-Caryophyllene

  • Directly activates cannabinoid receptors 

  • Antibacterial

  • Antifungal

  • Antitumor

  • Anti-inflammatory

  • Only terpenoid known to directly activate a cannabinoid receptor

  • Known for treating certain ulcers

  • Possible treatment for addiction

  • Antimalarial

  • Treatment of pruritus

  • Inflammatory conditions and autoimmune disorders

  • Antiseptic

Also found in: Thai basil, cloves, and black pepper, and has a rich spicy odor

Humulene

  • Antitumor

  • Antibacterial

  • Anti-inflammatory

  • Anorectic (suppresses appetite)

  • It has commonly been blended with β–caryophyllene and used as a major remedy for inflammation and is well known to Chinese medicine

 

Also found in: hops, cannabis sativa strains, and Vietnamese coriander, Humulene gives beer its hoppy aroma

PROMINANT TERPENES FOUND IN SANA SANA STRAINS

Ringo's Gift (ACDC x HarleTsu Hybrid):

  • β-Myrcene

  • α-Pinene

  • β-Pinene

  • Limonene

  • β-Caryophyllene

Purple Punch (Granddaddy Purple x Larry OG):

  • β-Caryophyllene

  • α-Caryophyllene

  • β-Myrcene

  • α-Pinene

  • β-Pinene

  • Linalool

  • Fenchol, antibacterial, antimicrobial, antioxidant

  • Ocimene

  • Terpineol

 
 
EXPLORE SANA SANA

There are many ways to consume cannabis. Check out our product line that is comprised of strain-specific, whole flower medicinal cannabis products that are either CBD-dominant or THC-dominant, ranging from Micro Dose to High Dose, as well as body care and skincare products that are CBD-rich. 

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Government Warning

GOVERNMENT WARNING: THIS PRODUCT CONTAINS CANNABIS, A SCHEDULE I CONTROLLED SUBSTANCE. KEEP OUT OF REACH OF CHILDREN AND ANIMALS. CANNABIS PRODUCTS MAY ONLY BE POSSESSED OR CONSUMED BY PERSONS 21 YEARS OF AGE OR OLDER UNLESS THE PERSON IS A QUALIFIED PATIENT. THE INTOXICATING EFFECTS OF CANNABIS PRODUCTS MAY BE DELAYED UP TO TWO HOURS. CANNABIS USE WHILE PREGNANT OR BREASTFEEDING MAY BE HARMFUL. CONSUMPTION OF CANNABIS PRODUCTS IMPAIRS YOUR ABILITY TO DRIVE AND OPERATE MACHINERY. PLEASE USE EXTREME CAUTION.

FDA Warning

All information contained within this site is for reference purposes only and is not intended to substitute the advice given by a pharmacist, physician, or any other licensed health-care professional.

Sana Sana Formulas products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any health condition or disease.